Martin Lagging Selected Research

Inosine Triphosphatase

7/2021	Absence of interferon-λ 4 enhances spontaneous clearance of acute hepatitis C virus genotypes 1-3 infection.
10/2018	Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus.
1/2018	Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens.
6/2014	Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3.

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Martin Lagging Research Topics

Disease

48	Infections 10/2023 - 07/2005
22	Chronic Hepatitis C 01/2020 - 08/2005
19	Fibrosis (Cirrhosis) 01/2023 - 07/2005
12	COVID-19 10/2023 - 02/2021
8	Liver Diseases (Liver Disease) 10/2023 - 07/2005
6	Liver Cirrhosis (Hepatic Cirrhosis) 10/2023 - 01/2008
5	Virus Diseases (Viral Diseases) 10/2023 - 10/2006
4	Inflammation (Inflammations) 01/2020 - 10/2006
3	Anemia 01/2018 - 06/2014
3	Hepatitis C 01/2012 - 01/2005
2	Hemolytic Anemia 10/2018 - 01/2018
2	Hepatitis E 03/2016 - 08/2015
2	Insulin Resistance 01/2013 - 09/2012
1	Gastroenteritis 10/2023
1	End Stage Liver Disease 01/2023
1	Persistent Infection 12/2022
1	Hematologic Diseases (Blood Diseases) 10/2022
1	Reinfection 07/2021
1	Abdominal Pain (Pain, Abdominal) 10/2019
1	Chronic Hepatitis (Chronic Active Hepatitis) 08/2015
1	Measles 09/2014
1	Multiple Sclerosis 09/2014
1	Thrombocytopenia (Thrombopenia) 06/2014
1	Communicable Diseases (Infectious Diseases) 05/2014
1	Substance-Related Disorders (Drug Abuse) 05/2014
1	Obesity 01/2012
1	Body Weight (Weight, Body) 08/2007
1	Viremia 08/2007

Drug/Important Bio-Agent (IBA)

26	Ribavirin (Virazole)FDA LinkGeneric 01/2023 - 08/2005
24	InterferonsIBA 10/2022 - 10/2006
18	RNA (Ribonucleic Acid)IBA 12/2022 - 01/2005
11	Antiviral Agents (Antivirals)IBA 01/2019 - 05/2007
7	Immunoglobulin G (IgG)IBA 10/2023 - 09/2014
7	AntibodiesIBA 12/2022 - 07/2011
5	Messenger RNA (mRNA)IBA 10/2023 - 01/2013
4	VaccinesIBA 10/2023 - 01/2022
4	AntigensIBA 01/2023 - 09/2014
4	Proteins (Proteins, Gene)FDA Link 07/2022 - 10/2006
4	Inosine TriphosphataseIBA 07/2021 - 06/2014
3	WastewaterIBA 10/2023 - 02/2021
3	COVID-19 VaccinesIBA 01/2023 - 01/2022
3	Peptides (Polypeptides)IBA 10/2022 - 01/2022
3	InterleukinsIBA 01/2022 - 06/2011
3	Inosine Triphosphate (ITP)IBA 07/2021 - 06/2014
3	PyrophosphatasesIBA 07/2021 - 06/2014
3	Biomarkers (Surrogate Marker)IBA 01/2014 - 07/2005
3	peginterferon alfa-2a (Pegasys)FDA Link 08/2010 - 08/2005
2	grazoprevirIBA 01/2023 - 03/2015
2	elbasvirIBA 01/2023 - 03/2015
2	CytokinesIBA 01/2023 - 01/2022
2	Nucleocapsid ProteinsIBA 01/2022 - 09/2014
2	Complement System Proteins (Complement)IBA 03/2016 - 01/2014
2	Protease Inhibitors (Protease Inhibitor)IBA 03/2015 - 07/2012
2	Opiate AlkaloidsIBA 05/2014 - 05/2014
2	Prothrombin (Factor II)IBA 01/2014 - 07/2005
1	mRNA VaccinesIBA 10/2023
1	Interleukin-6 (Interleukin 6)IBA 01/2023
1	Amino Acids FDA Link 10/2022
1	BNT162 VaccineIBA 10/2022
1	2019-nCoV Vaccine mRNA-1273IBA 10/2022
1	Viral RNAIBA 09/2022
1	Indicators and Reagents (Reagents)IBA 09/2022
1	Interleukin-12 (IL 12)IBA 01/2022
1	Interleukin-17 (Interleukin 17)IBA 01/2022
1	Interleukin-2 (IL2)IBA 01/2022
1	Interleukin-13IBA 01/2022
1	Vitamin D FDA LinkGeneric 01/2020
1	hydroxide ionIBA 01/2020
1	EnzymesIBA 10/2019
1	paritaprevirIBA 01/2018
1	Complement C3 (C3 Complement)IBA 01/2018
1	Ritonavir (Norvir)FDA Link 01/2018
1	ombitasvirIBA 01/2018
1	CollagenIBA 01/2018
1	SofosbuvirIBA 01/2017
1	Cartilage Oligomeric Matrix ProteinIBA 01/2017
1	Immunoglobulin M (IgM)IBA 03/2016
1	Interferon LambdaIBA 01/2015
1	Phospholipases (Phospholipase)IBA 01/2015
1	NucleoproteinsIBA 09/2014
1	Oligoclonal BandsIBA 09/2014
1	SterolsIBA 01/2014
1	CholesterolIBA 01/2014
1	lathosterolIBA 01/2014
1	ChemokinesIBA 01/2013
1	Interferon-gamma (Interferon, gamma)IBA 05/2010
1	Glycyrrhizic Acid (Glycyrrhizin)IBA 10/2006
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 07/2005

Therapy/Procedure

26	Therapeutics 02/2019 - 10/2006
5	Duration of Therapy 01/2023 - 03/2011
4	Liver Transplantation 12/2022 - 06/2012
3	Hematopoietic Stem Cell Transplantation 08/2023 - 01/2022
1	Stem Cell Transplantation 10/2023
1	Transplantation 10/2022
1	Blood Transfusion (Blood Transfusions) 01/2017
1	Opiate Substitution Treatment 05/2014
1	Retreatment 07/2013
1	Injections 10/2006